uWorkin

Job No.: 614321

Location: Parkville campus

Employment Type: Full-time

Duration: 12-month fixed-term appointment

Remuneration: $69,401 - $94,190 pa Level A (plus 9.5% employer superannuation)

The Opportunity

Join with one of the world’s leading research groups applying structural biology and advanced analytical pharmacology approaches to tackle key questions on the function of G protein-coupled receptors (GPCRs), the largest family of membrane drug targets. The successful candidate will be part of innovative research integrating cryo-electron microscopy, pharmacology and computational chemistry to understand the interaction of natural ligands and drugs with their GPCR targets, how these interactions control signalling, and the application of this knowledge to novel drug discovery and development.

The candidate's responsibilities: You will apply your experience to the isolation of GPCRs that will be used for cryo-EM structure determination and/or biophysical and biochemical study of GPCR function. You will contribute to the determination of the structure of GPCRs and their complexes with drugs and signaling proteins using cryo-EM. You will work within a broader team integrating membrane protein biochemistry, high-resolution cryo-EM structure determination, molecular and analytical pharmacology and medicinal chemistry to understand and modulate GPCR function.

The candidate's attributes: You will have a PhD in an appropriate discipline and extensive experience in membrane protein biochemistry, preferably with additional specific expertise in structural characterisation of membrane proteins by cryo-EM. Specific experience working with GPCRs would be desirable. You will be able to work both independently and seamlessly within a larger team environment, including application of highly developed technical skills, and rapid ability to learn new techniques.

To view the position description and instructions on how to apply please click here

Enquiries

Professor Patrick Sexton, Professor Pharmacology, Director, ARC Centre for Cryo-electron Microscopy of Membrane Proteins, patrick.sexton@monash.edu

Closing Date

Wednesday 3 March 2021, 11:55 pm AEDT